Urlrlary tract infections are amongst the mot common pathogenlc infections with an tncreasing resistence to antimicrobials. Isolates from urine samples were identified and their susceptibility to antirrdcrobial agents were studied, also synergetic and antagonism Of the combined antibtotics against bacterial isolates and electron microscope study agabtSt multi-drug reslStent bacteria were studted , During the study. 211 urine samples from diabetic and non diabetic female patient were analysed, of which 115 had signiflcant bacteriuria (98 from diabetic and 17 from non diabetic)_ Fot diabetic patient. Eschertchia coll was the most common ettologic agent 27 (27.6%) followed by Serratia 12{ 12.2%), Citrobacter, Enerobacter and Micrococci each one was J 0( 10.2%) . Salmonella 7(7,1%). Pseudomonas aeruglnosa and Coagulase negative staphylococci each one was 6{6.l%). Proteus 5(5.1%), Staphylococcus aureus and Shigella each one was 2 (2%) and Streptococi l(l%).