This study was carried out from april to November 2005 in demietta and dakahlia governorates. Atotal of(4417)cattle and (756) buffaloes were examined clinically for lumpy skin disease. Out of them (1143) cattle and (5) water buffaloes showed skin nodules of LSD. Different clinical forms, acute and subacute were noticed. The study revealed total morbidity and mortality rates in cattle were(25.87%, 3.28%)respectively, whereas in buffaloes were (0.66%,0,0%) respectively. Higher morbidity rate was recorded in adult cattle either vaccinated herds (19,6) or non-vaccinatedherds (42.9%)while higher mortality rate was recorded in suckling calves (2.71%) in vaccineated herds and (8.08%)in non-vaccinated herds. The higher incidence was recorded in summer in cattle and buffaloes the emergency vaccination by local produced sheep pox vaccine was used against lutnpy skin disease outbreak and it succeeded in lowering the economic losses minimizing the morbidity and abortion rates in vaccinated herds compared to non-vaccinated one the vaccinated herds showed morbidity rate (14.36%) mortality rate ( 1.13%) and abortion rate ( 0.55%) whereas non-vaccinated herds showed morbidity rate (33.5%) morality rate ( 4.7%) and abortion rate (6.62%) eighty two different sample were collected during the outbreak for virus isolation from cattle (buffy coat 25 lymph nodes biopsy 10 skin biopsy 35 tracheal plague 2 and saliva 10 ) and 5 buffy coat from buffalos all samples were processed for virus isolation isolated virus from cattle and buffaloes wereidentified by using SNT and IFAT serum samples were collected from clinically diseased and in- contact animals (cattle 250 and buffalo 25 ) . Antibodies were deceted in all serum samples by varied titer by using SNT and ELISA as the mean titer by SNT were (64 128 32 ) and by ELISA were (3200 4200 2000) in early infection late infection and in – contact animals respectively were (32 . 16 ) by SNT and ( 1400 1200 ) by ELISA in diseased and in – contact animals respectively the isolated viruses from cattle and buffaloes were inoculated subcutaneously in susceptible cattle the cattle virus was caused a generalized reaction while buffaloes virus were producing localized reaction it could be concluded that : the severity of LSD outbreak Egypt 2005 LSD of cattle occasionally affecting buffaloes with variant degree of severity local produced sheep pox vaccine succeeded in protection against the disease .