As the blood sucking insects reproduction starts with spring and summer seasons so the vaccination against arthropod born infections should be carried out before or at these seasons. The present study was aimed to evaluate the vaccination of cattle against bovine ephemeral fever (BEF) and lumpy skin disease (LSD). So different groups of calves were vaccinated singly, alterative and simultaneously with locally produced inactivated BEF and live attenuated sheep pox vaccine (as a non-specific vaccine) used to protect cattle against LSD. Both cell mediated and humoral immunity were evaluated in such animals. It was found that the highest immune levels against BEF were obtained by 2 doses with 2 weeks in between or one dose followed the vaccination with sheep pox vaccine which reacted as a non-specific immunostimulant, it was also noticed that BEF vaccine did not antagonize the animal response to sheep pox vaccine.