In a trial to evaluate the safety, reactogenicity and immunogenicity of PPR and Brucella vaccines when given simultaneously to susceptible sheep, these sheep were divided into 4 groups : group one vaccinated against PPR, group 2 vaccinated against PPR and Brucella( using Brucella melitensis Rev 1 vaccine), group 3 vaccinated against Brucella using Rev 1 vaccine and group 4was left unvaccinated as control. The results obtained were identical serologically for PPR and Brucella vaccines when given solely but when given simultaneously, Brucella live vaccine act as adjuvant and lead to increase the immune response against PPR vaccine but PPR living attenuated vaccine suppress the immune response against Brucella vaccine, results were discussed.