During examinination and treatment of cattle and bulffalo fascioliasis in Imbaba distrcts of Giza Province, 1074 cattle fecal samples and 1477 buffalo fecal samples were examined microscopically of detection of Fasciola eggs. The prevalence rates of fascioliasis in cattle and buffaloes were 8.3% and 7.6% respectively. The highest prevalence recorded among cattle and buffaloes were 13.4% and 14.6% respectively, during the winter season. In addition, higher prevalence rates (12.3% and 10.3%) were recorded among cattle in Bani-Salama and Atris districts, respectively. Concerning buffaloes, higher prevalence rates were also recorded in Atris and Nekla districte 9.8% and 7.5% respectively. Triclabendazole (Fasinex 10%), was used to treat positive cases and related contacts, owned by the same owner. At a dose rate of 12 mg/kg body weight. After six months, the prevalence rate of fascioliasis dropped sharply form 10.3% and 9.8% to about 0.9% and 1.2% among cattle and buffaloes respectively. In Atris district which subjected to re-examination. It could be concluded that continuous non-intereupted examination and treatment of animal fascioliasis in a locality is of greavalue in lowering prevalence rates in such a locality with all the consequences of reducing economic losses of animal fascioliasis.