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127989

HISTOPATHOLOGICAL ALTERATIONS IN INTESTINE OF MICE INFECTED WITH OF SCHISTOSOMA MANSONI

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Parasitology

Abstract

Schistosomiasis remains an important health problem in many tropical countries and developing countries. It has serious pathological lesions in different tissues particularly liver. The aim of this study is to demonstrate histopathological alterations in intestine of mice infected with S. mansoni as model for human schistosomiasis. Twenty mice were infected by tail immersion technique (80±10 cercariae per mouse of Egyptian strain of S. mansoni). Animals were clinically observed for 7 weeks and then they were sacrificed. Gross and histological examination was done, in addition to Masson trichrome and scoring of fibrosis by image J analysis were performed. The results revealed severe weight loss of infected mice compared to control one, large number of neutrophiles in granuloma of S mansoni in intestinal submucosa, extensive fibrosis, about 12% from total area of intestine, that penetrate deeply into muscle layer. it was concluded that S. mansoni caused pyogranulomatous enteritis and extensive fibrosis that extended deeply into muscle layer of intestine.

DOI

10.21608/mvmj.2017.127989

Keywords

Mice, Schistosoma mansoni

Authors

First Name

Mohamed

Last Name

Hamed

MiddleName

F

Affiliation

Lecturer of pathology, pathology department, Mansoura University, Egypt, 35516

Email

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City

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Orcid

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First Name

Moustafa

Last Name

Al-Araby

MiddleName

A.

Affiliation

Lecturer of parasitology, parasitology department, Mansoura University, Egypt, 35516

Email

-

City

-

Orcid

-

Volume

18

Article Issue

1

Related Issue

17809

Issue Date

2017-06-01

Receive Date

2017-09-12

Publish Date

2017-12-12

Page Start

581

Page End

585

Print ISSN

1110-7219

Online ISSN

2682-2512

Link

https://mvmj.journals.ekb.eg/article_127989.html

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https://mvmj.journals.ekb.eg/service?article_code=127989

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50

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

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Article

Created At

22 Jan 2023