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127611

ADVERSE EFFECTS OF LINCOMYCIN AND SPECTINOMYCIN IN RATS

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Pharmacology and toxicology

Abstract

This study was performed to investigate the adverse effects of lincomycin (given orally at 500 mg/kg daily for 21 days) and spectinomycin (given S.C at 250 mg/kg daily for 30 days) on 24 apparently clinically healthy adult male albino rats (175 - 250 gm). Blood, serum and tissues (Liver, kidney and testis) samples were collected for hematological, biochemical and histopathological for investigation. The obtained results revealed that, lincomycin and spectinomycin treated groups showed a significant decrease in total erythrocytic and leucocytic count (especially lymphocytes), hemoglobin values and PCV value. The levels of ALT, AST, cholesterol, triglycerides and LDL revealed a significant increase in lincomycin and spectinomycin treated groups. While the level of HDL showed a significant decrease in both lincomycin and spectinomycin treated groups. The results also showed that, both drugs induced histopathological alterations in the liver, kidney and testis.

DOI

10.21608/mvmj.2017.127611

Keywords

LINCOMYCIN, SPECTINOMYCIN, Rats

Authors

First Name

S.

Last Name

Amer

MiddleName

A

Affiliation

Pharmacology Department, Fac. Vet. Med, Mansoura University

Email

-

City

-

Orcid

-

First Name

Reham

Last Name

A

MiddleName

A.

Affiliation

Pharmacology Department, Fac. Vet. Med,

Email

-

City

-

Orcid

-

First Name

Enjy

Last Name

R

MiddleName

F.

Affiliation

Clinical Pathology Department., Fac. Vet. Med., Mansoura University

Email

-

City

-

Orcid

-

First Name

Hamza

Last Name

M

MiddleName

H

Affiliation

Pharmacology Department, Fac. Vet. Med,

Email

-

City

-

Orcid

-

Volume

18

Article Issue

1

Related Issue

17809

Issue Date

2017-06-01

Receive Date

2017-09-12

Publish Date

2017-12-12

Page Start

503

Page End

519

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 18_Issue 1_Pages 503-519.pdf

PDF . 3.3MB

Link

https://mvmj.journals.ekb.eg/article_127611.html

Detail API

https://mvmj.journals.ekb.eg/service?article_code=127611

Order

32

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023