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126439

EFFECT OF FLAXSEED ON SERUM LIPIDS AND ATHEROSCLEROSIS IN RABBITS

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Last updated: 04 Jan 2025

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Tags

Biochemistry and Physiology

Abstract

This study was carried out to investigate the beneficial effect of flaxseed-rich diet on atherosclerotic rabbits. Rabbits were divided to 4 groups: group I, control diet, group II,1%cholesterol diet, group III, 10% flaxseed diet, and group IV, 1% cholesterol+ 10% flaxseed diet. Blood and tissue samples were collected after 2 months for measurement of serum lipid profile :total lipids, total cholesterol (TC), triacylglycerol (TAG), HDL-cholesterol (HDL-C), LDL- cholesterol(LDL-C) ;blood and tissue antioxidants :reduced glutathione (GSH) ,superoxide dismutase (SOD) and catalase ;oxidative stress parameters :nitric oxide(NO) ; serum lipid peroxidation product : malondialdehyde (MDA) and histopatholgical examination of aorta. The results of the current work indicated that dietary cholesterol supplementation significally increased lipid profile parameters ;total lipids, total cholesterol(TC), triacylglycerol (TAG), HDLcholesterol (HDL-C) and LDL-cholesterol (LDL-C),MDA and tissue SOD. On the other hand, cholesterol supplementation reduce NO, catalase, blood SOD and blood GSH but there was no change in tissue GSH .Also the result indicated that cholesterol and flaxseed supplementation on the same time lead to increase lipid profile parameters (total lipids, total cholesterol (TC), HDLcholesterol (HDL-C) and LDL-cholesterol (LDL-C) but not affect triacylglycerol (TAG), also, increase MDA, NO, catalase and tissue SOD but not affect blood SOD and decrease blood GSH , but not changed in tissue. On the other hand flaxseed supplementation alone was resulted in increased total lipids ,slight increase in total cholesterol (TC) ,there was no change in triacylglycerol (TAG), decrease HDL-cholesterol (HDL-C) ,increase LDL- cholesterol(LDL-C), no change in MDA and NO, increase blood catalase, liver GSH, but decrease tissue catalase ,blood GSH. from these results it can be concluded that flaxseed assured no protection against atherosclerosis in cholesterol fed rabbits.

DOI

10.21608/mvmj.2017.126439

Keywords

Atherosclerosis, Rabbits, Flaxseed

Authors

First Name

El- Said

Last Name

El- Sherbini

MiddleName

El-Said

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Egypt

Email

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City

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Orcid

-

First Name

Gehad

Last Name

El-sayed

MiddleName

R

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

El-sebaei

MiddleName

G

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

Hassan

MiddleName

-

Affiliation

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

Volume

18

Article Issue

1

Related Issue

17809

Issue Date

2017-06-01

Receive Date

2017-09-12

Publish Date

2017-12-12

Page Start

263

Page End

271

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 18_Issue 1_Pages 263-271.pdf

PDF . 724.6kB

Link

https://mvmj.journals.ekb.eg/article_126439.html

Detail API

https://mvmj.journals.ekb.eg/service?article_code=126439

Order

12

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

EFFECT OF FLAXSEED ON SERUM LIPIDS AND ATHEROSCLEROSIS IN RABBITS

Details

Type

Article

Created At

22 Jan 2023