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198481

IMPACT OF INSULIN PRODUCING STEM CELLS DERIVED from HUMAN BONE MARROW ON SOME DIABETIC COMPLICATIONS

Article

Last updated: 04 Jan 2025

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Tags

Biochemistry and Physiology

Abstract

Stem cells were derived from adult human bone marrow. After differentiation cells were encapsulated in the rectus abdominus sheath of diabetic dogs. Eighteen mongrel dogs were divided into three groups: normal non-diabetic group (6), diabetic untreated group (6), and treated group (6). Blood glucose levels was improved to be like normal range in diabetic dogs treated with stem cells. Lipid profile including triacylglycerol, HDL-C, LDL-C and cholesterol levels were significantly higher in diabetic untreated dogs and showed a significantly lowered levels in stem cells treated dogs than that in diabetic dogs and become nearly to normal dogs. ALT activities of diabetic dogs with treatment slightly improved than non- diabetic and diabetic untreated groups while AST activities returned to be as in normal group. Creatinine levels of untreated diabetic dogs was significantly higher than those of treated diabetic dogs and improved to be as in normal dogs. In this study, we successfully induced the differentiation of MSCs into functional insulin producing cells (IPCs) by transplanting IPCs into chemically induced diabetic dogs, it was found that IPCs were capable to improve blood glucose levels and so decrease the lipid profile, kidney function and liver function. Keywords: Dog, Hyperlipidemia, Lipid profiles, liver function, Kidney function, stem cells, diabetes mellitus.

DOI

10.21608/mvmj.2018.198481

Authors

First Name

Maha

Last Name

Azzam

MiddleName

-

Affiliation

Department of physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Gabr

MiddleName

-

Affiliation

Urology and Nephrology center, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Nabil

Last Name

Abuheakal

MiddleName

-

Affiliation

Department of physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ghoneim

MiddleName

-

Affiliation

Urology and Nephrology center, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

17732

Issue Date

2018-06-01

Receive Date

2018-02-01

Publish Date

2018-06-01

Page Start

101

Page End

110

Print ISSN

1110-7219

Online ISSN

2682-2512

Article File

MVMJ_Volume 19_Issue 1_Pages 101-110.pdf

PDF . 610.8kB

Link

https://mvmj.journals.ekb.eg/article_198481.html

Detail API

https://mvmj.journals.ekb.eg/service?article_code=198481

Order

16

Type

Original Articles

Type Code

1,268

Publication Type

Journal

Publication Title

Mansoura Veterinary Medical Journal

Publication Link

https://mvmj.journals.ekb.eg/

MainTitle

IMPACT OF INSULIN PRODUCING STEM CELLS DERIVED from HUMAN BONE MARROW ON SOME DIABETIC COMPLICATIONS

Details

Type

Article

Created At

22 Jan 2023