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Role of MR Spectroscopy in Evaluation of Posterior Fossa Tumors in Children

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Last updated: 25 Dec 2024

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Abstract

This study aims to go over the most common tumors of posterior fossa affecting children, with emphasis on their Magnetic Resonance Imaging “MRI" findings and Magnetic Resonance “MR" Spectroscopy, to improve histological approach in imaging, helping the management and approach for surgeons in providing information to the patients' parents. It was a prospective study carried out on 20 patients with posterior fossa tumors. The patients were referred to Radiology Department of AL-Zahraa University Hospital for MRI and MR Spectroscopy examination after getting approval from ethical committee. A written informed consent was taken from parents. This study was conducted for a period of six months from May 2021 to October 2021. 20 patients ages ranged 3-14 years. Eight were males and twelve were females. Incidence of pilocytic astrocytoma 8 cases (40%), ependymoma 6 cases (30%), medulloblastoma 4 cases (20%) and atypical teratoid rhabdoid tumor 2 cases (10%). Their distribution in the posterior cranial fossa was 2 cases at the pons (10%), 4 cases at the cerebellum (20%), 10 cases at the fourth ventricle (50%), 2 cases at the midline posterior fossa (10%) and 2 cases at the CPA (10%). Different metabolite peaks were evaluated from resulting MR spectra, including choline, NAA, creatine, lipid, lactate, myoinositol and taurine peaks. Metabolite ratios, such as Cho/Cr and Cho/NAA ratios, were used for diagnosis and differentiation of different tumor types. We concluded MR spectroscopy is a powerful tool in diagnosis of posterior fossa tumors in pediatric patients and determination of tumor grades because it enables biochemical assessment of tumor dynamics.

DOI

10.21608/aujv.2022.276730

Keywords

MR Spectroscopy, Posterior fossa, Tumors, children

Volume

4

Article Issue

4

Related Issue

38481

Issue Date

2022-12-01

Receive Date

2022-08-28

Publish Date

2022-11-01

Page Start

40

Page End

48

Print ISSN

3009-7819

Online ISSN

3009-6685

Link

https://aujv.journals.ekb.eg/article_276730.html

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https://aujv.journals.ekb.eg/service?article_code=276730

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5

Type

Original Article

Type Code

1,261

Publication Type

Journal

Publication Title

Al-Azhar University Journal of Medical and Virus Researches and Studies

Publication Link

https://aujv.journals.ekb.eg/

MainTitle

Role of MR Spectroscopy in Evaluation of Posterior Fossa Tumors in Children

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Article

Created At

22 Jan 2023