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270583

Effect of Fenugreek, Nigella Sativa and Green Tea Mixture on Liver Function, Oxidative–Antioxidant Balance and Vitamin D Metabolism in Patients with HCV-Related Liver Cirrhosis

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Last updated: 25 Dec 2024

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Abstract

Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality that is responsible for hepatic inflammation and the formation of scar tissue (fibrosis) by release of free radicals and impaired vitamin D metabolism. We aimed to assess the effect of herbal therapy on serum vitamin D and free radicals and antioxidants in patients with HCV-related liver cirrhosis (LC). The study incorporated 48 patients with HCV-related LC and 22 healthy controls. Out of cirrhotics, 24 patients received one spoonful of herbal mixture composed of equal volumes of mixed powder of fenugreek, Nigella sativa and green tea two times daily for 2 months. Liver function tests, serum oxidative stress malonaldahyde (MDA), antioxidant superoxide dismutase (SOD), reduce glutathione (GSH), vitamin D (25OH-D3) and parathyroid hormone (PTH) were estimated. Significantly improved liver function, 25OH-D3 and antioxidants (SOD, GSH) and decreased oxidative stress indicator (MDA) levels in herbal treated cirrhotics than non-herbal treated patients but they still impaired compared to healthy controls. Herbal administration may attain significant improvement in liver function, oxidative–antioxidant balance and vitamin D metabolism in patients with HCV- related LC.

DOI

10.21608/aujv.2022.270583

Keywords

liver disease, Herbal Treatment-25OH-D3, PTH

Volume

4

Article Issue

3

Related Issue

37712

Issue Date

2022-09-01

Receive Date

2022-03-20

Publish Date

2022-09-01

Page Start

41

Page End

49

Print ISSN

3009-7819

Online ISSN

3009-6685

Link

https://aujv.journals.ekb.eg/article_270583.html

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https://aujv.journals.ekb.eg/service?article_code=270583

Order

5

Type

Original Article

Type Code

1,261

Publication Type

Journal

Publication Title

Al-Azhar University Journal of Medical and Virus Researches and Studies

Publication Link

https://aujv.journals.ekb.eg/

MainTitle

Effect of Fenugreek, Nigella Sativa and Green Tea Mixture on Liver Function, Oxidative–Antioxidant Balance and Vitamin D Metabolism in Patients with HCV-Related Liver Cirrhosis

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Type

Article

Created At

22 Jan 2023