Ambulatory anesthesia allows quick recovery from anesthesia, leading to an early discharge and rapid resumption of daily activities, which can be of great benefit to patients, healthcare providers, third-party payers, and hospitals. To compare hyperbaric prilocaine 2% (takipril) with hyperbaric bupivacaine 0.5% for day-case spinal anesthesia in the term of primary outcome which is the time to sensory and motor block regression and secondary outcome in the form of time to home readiness, early ambulation, incidence of complications in saddle area surgeries. This study was carried out in Al-Azhar University hospitals (Al-Zahraa hospital) and included 46 patient aged 18 to 65 years of both sexes undergoing saddle perianal operations under spinal anesthesia. Patients were randomly allocated into two equal groups 23 patients in each group. In our study was that day-case spinal anesthesia with prilocaine 40 mg +20 μg fentanyl provide faster sensory block onset, regression in Group P than in Group B (136.91 ± 12.81 min versus 201.30 ± 19.69 min) as primary outcome and home readiness for Group P than for Group B (186.43 ± 30.75 min versus 231.39 ± 25.61 min) with less complication as secondary outcome compared with 10 mg bupivacaine + 20 μg fentanyl for day case spinal anesthesia. Hyperbaric prilocaine + fentanyl is superior to hyperbaric bupivacaine + fentanyl in the term of primary outcome which is earlier sensory and motor block regression and secondary outcome in the form of home readiness, early ambulation and complication, so we recommended hyperbaric prilocaine for day- case surgery in saddle area surgeries.