The "proteome" is the entire protein composition of a cell that is described at a given moment in terms of localisation, interactions, post-translational changes and turnover. Although it is far more complicated than genomics, proteomics is one of the most important methodologies for understanding gene function. It is critical for early illness diagnosis, prognosis and disease progression monitoring. It also plays an important function in medication development as target compounds. Biological fluids obtained from individuals with Auto Immune Diseases (AIDs) may be used to profile autoantibody reactions and proteomics methods have proven to be quite useful in this process. To identify proteins, proteomics methods such as tissue array and mass spectrometry (MS) in various forms are used. Scientists attempting to identify novel biomarkers in illnesses such as AIDs have recently been more interested in protein microarray technology. The goal of this study was to bring attention to the latest developments in proteomic analysis and to determine its function and clinical value in the diagnosis of autoimmune disorders.