Stress urinary incontinence is the most common type of UI in women and defined as in voluntary loss of urine on effort, physical exertion, or on sneezing or coughing. It is considered one of the most common dysfunctions of the lower urinary tract and represents a worldwide problem affecting people of all ages and across different cultures and races. Platelet-rich plasma (PRP) is becoming more common as a non-operative therapy choice for a wide spectrum of medicinal disturbances including stress urinary incontinence. To assess the efficacy and feasibility of platelet rich plasma injections in the treatment of stress urinary incontinence in postmenopausal women. Patients and Methods: Prospective randomized clinical study was conducted at the Department of Obstetrics and Gynecology, Al-Zahra University Hospital between June 2020 and June 2021 on selected thirty postmenopausal women with complaint of stress urinary incontinence. All thirty women had received a treatment with Platelet Rich Plasma injections in pubocervical fascia by specialized technique in one session and the 2nd injection was done when the patient need after two months. In this study the improvement in stress urinary incontinence after1st injection of PRP was in 11 cases with percentage of 36.7 % of cases in addition to complete cure of 8 cases with percentage of 26.7 % of cases. After two injections of PRP, complete cure of 14 cases, improvement in degree of severity in 11 cases and only 5 cases not improved in grade of severity of incontinence with percentage of 16.7 % of the cases. Local injection of autologous platelet rich plasma has a curative effect on females suffering from stress urinary incontinence with high efficacy and success rate.