Preeclampsia is a common complication of pregnancy and remains a common cause of maternal and fetal mortality. The clinical symptoms of preeclampsia are caused by widespread endothelial dysfunction suggested to be a part of an exaggerated maternal inflammatory response to pregnancy. The objective of this study is to estimate serum amyloid A in pregnant women with preeclampsia. Type of study: Case control study. Study period: from Septemper2019 to August 2021. Study population: The study was carried out on 75 women divided into three groups: Group I (25 women): The control group are healthy pregnant women who had an uncomplicated antenatal course. Group II (25 women): They are women with mild preeclampsia. Group III (25 women): They are women with severe preeclampsia. Serum amyloid A level (SAA) varied significantly in severe preeclampsia compared to mild and control groups. There was statistically significant positive correlation between serum amyloid A level and most of the indices of severity of preeclampsia, including systolic and diastolic blood pressure, liver transaminases, serum creatinine and albuminuria.