The efficiency of some systemic fungicides and resistance inducing chemicals (RICs) on management of cantaloupe powdery mildew, caused by Erysiphe cichoracearum DC, was evaluated under greenhouse and field conditions. Greenhouse experiments revealed that application of the tested systemic fungicides, i.e., Master 10%, Rubigan 12%, Sumi-8 5%, Topas 10% and Vectra 10% as well as RICs, i.e., Bion, calcium chloride, potassium dibasicphosphate and salicylic acid, significantly reduced the disease severity, meanwhile plant length and foliage fresh weight were increased in comparison with check treatments. However, systemic fungicides were more efficient in this concern than the tested RICs. Under field conditions, application of either Master 10%, Rubigan 12% or Vectra 10% followed by spraying of calcium chloride or salsylic acid caused significant decrement in the disease severity with significant increment in the fruit yield when compared with check treatments. However, these treatments were, to somewhat, less efficient than application of systemic fungicides only.