Three nutritional elements, i.e. manganese, zinc and calcium as well as fungicide plantvax 20% EC, were evaluated for their efficacy to control rust disease in faba bean. Under artificial inoculation at greenhouse, a significant reduction in rust disease severity was found as a result of spraying faba bean plants with plantvax 20% EC, calcium, zinc and manganese, respectively, compared to the control. Same trend of results recorded in the field experiments conducted under natural infection at four locations, i.e. Itay El-Baroud, Tag Elez, El-Gemmeiza and Sers-Ellyan, Nevertheless, minor differences among the locations were noted. Tested treatments improved plant growth (plant height) and yield (number of pods/plant and weight of 100 seeds) over the control. Calcium, zinc and manganese applications increased activity of chitinase and B-1,3-glucanase enzymes. Such increases in enzymatic activities may be responsible for controlling rust disease in faba bean.