The efficiency of some inducing resistance chemicals (IRCs) and systemic fungicide were evaluated in vitro on suppressing the germination of uredospores of Puccinia triticina as well as controlling leaf rust of wheat under greenhouse and field conditions. Different degrees of inhibition to the germinated uredospores of P. triticina were occurred when sprayed the tested IRCs, i.e. ascorbic acid, oxalic acid, sodium salicylate, di-basic potassium phosphate, salicylic acid and benzothiadiazole (BTH) and the systemic fungicide, i.e. propiconazole (Tilt). Furthermore, the used systemic fungicide was more efficient than IRCs in this regard. Spraying two wheat varieties (Giza168 and Giza139) with the tested IRCs and fungicides reduced significantly the severity of leaf rust disease compared with control treatment under greenhouse conditions. On the other hand, spraying the two wheat cultivars under field conditions during 2011/2012 growing seasons in two Governorates (El-Sharkiya and Kafr El-Sheikh) with the tested IRCs and fungicides resulted in a significant decrease in the severity of the disease compared with control treatment. In addition, the tested IRCs were low disease efficient comparing to treatments sprayed with the fungicide. All the tested IRCs resulted in a significant increment in yield components, while the fungicide (Tilt) show low efficient in yield components as compared to the control treatment.