Five biofertilizers and two biofungicides were tested for their efficacy to control Phytophthora root-rot of apple and mandarin trees during two growing seasons of 2009/10 and 2010/11 in South El-Tahrir, Behera Governorate, Egypt. For apple trees, Phosphorein caused the highest reduction in disease severity, while Bioarc and Phosphorein were the most effective against Phytophthora root-rot of apple trees. Meanwhile, Biogen caused the highest reduction in Phytophthora cactorum counts, either in rhizosphere or in colonized roots of apple trees. Moreover, Nitrobin and Bioarc recorded the highest reduction in disease severity on mandarin trees, while Phosphorein and Bioarc were the most effective in this concern. Bioarc and Biogen caused the highest reduction in P. parasitica counts and Biogen recorded the highest reduction in its frequency colonized roots and rhizosphere on mandarin trees. Generally, applying the tested biofertilizers and biofungicides caused high reduction in Phytophthora root-rot of apple and mandarin trees and also reduced the delirious effects on the environment and the fruits.