Laboratory study and field trials were conducted to verify the effectiveness of some recommended fungicides in controlling Cercospora leaf spot (CLS) of sugar beet. These fungicides are: Score, Eminent, Montro, Opus, Foliogold and Amistar. All fungicides at 10 ppm conc. significantly reduced the radial growth of C. beticola in the Lab. Score, Eminent, Montoro and Opus provided high levels of efficacy. Amistar (Azoxystrobin) and Foliogold (chlorothatonol) gave the lowest effect in reducing the growth rate compared with Trizole fungicides. The same trend was found in the field where Score and Eminent were the most effective fungicides in controlling CLS disease. Fungicides treatment caused significant increase in yield and quality traits (root weight, total soluble solids (T.S.S.) %, sucrose % and purity%) comparing with control plots. Also, T.S.S%, sucrose% and purity% were increased in root samples stored 15 days after harvest. Treating with Score and Eminent were the most efficient in this respect. Determination of residues in the produced beet roots proved the degradation and safety of using these two fungicides, which belong to tetraconazole and difenoconazole in the sugar beet roots. The results are coincided with the allowed limits of the maximum residual limit (MRL) according to FAO and WHO and EU database.