Changing organizational structure is considered undesirable for many organizations. They fear uncertain situations. As a result, many questions came to mind and many hopes as well. However, change becomes necessary particularly for nonprofit organization like the World Health Organization. The new leader, Dr. Chan, and the headquarters thought that structural change could open opportunities for development in WHO budget, health solutions, technology information system, and collaborative processes with other agencies and governmental and nongovernmental organizations. That influences the WHO internal communication system strategies, and increases the ability to achieve WHO main objectives. The WHO has the most complicated and decentralized structures that continued it is participation strategy in the decision-making process, and applied more delegation through its communication channels. Moreover, WHO applied changes in positions, individuals, and policies. WHO continued to trust that collaborative and team inspiration, and effective health technology system are the basic internal communication strategies to achieve WHO health goals. Dr. Chan, her team, and WHO headquarters including WHO membership agreed to choose the most experienced department heads and other leaders to energize the structures with qualified expertise. WHO governors emphasize the delegated strategy in order to balance its power between WHO leaders and WHO country offices for more ethical and appropriate decisions.