Abstract: This research aimed to identify the relationship betweenpsychological immunity of blind children's mothers and the self-esteem of their children. The research exploratory sample included(90) mothers of blind children. And The research main sample included(30) mothers of blind children of kindergarten at(4-7) years old. in Cairo governorate The necessary tools were built to be used in achieving the desired goals, which are the online electronic scale of the psychological immunity of blind children's mothers(researcher's preparation), the online electronic scale of perceived self-esteem of blind children(researcher's preparation. The descriptive approach was used to reveal the relationship between the variables, and the researcher used statistical methods(mean, regression analysis, Pearson correlation coefficient, Kronbach's alpha stability coefficient, factor analysis). Restults of appling this reasearch is summerized as the following: There is a statistically significant correlation between the psychological immunity of mothers and the self-esteem of their blind children. Blind children's self-esteem can be predicted by psychological immunity of their mothers.