This study aims to examine the effect of the dimensions of Open-Book Management (OBM), named Employee Empowerment, Employee Training, Sharing Information, and Employee Rewarding System on Innovative Behavior for Demonstrators and Lecturer Assistants in Mansoura University. The questionnaire was used as a data gathering tool in this study. which was directed to 500 demonstrators and lecturer's assistants of Mansoura University. Only 359 questionnaires were statistically valid and free of missing data. Path analysis was employed to test the research hypotheses through Warp PLS 7 program. The study results indicated that there were direct positive significant effects Open-Book Management (Employee Empowerment, Employee Training, Sharing Information, and Employee Rewarding System) on Innovative Behavior.