All health professionals, especially nurses, confront numerous stressors within their clinical practice, including time pressures, workload, multiple roles, and emotional issues. Workplace stress can affect negatively moral courage and the physical and mental well-being of health professionals. These outcomes can influence not only the well-being of nursing professionals, and vocational moral courage but also on their ability to practice effectively, beside that, can reduce the quality of their nursing care services and therefore, negatively affect patient outcomes. Aim: The current study aims to systematically explore relationship between work resilience and vocational moral courage, and psychological well-being among nurses. Design: A descriptive, correlational research design was utilized to achieve the aim of the study. Method: The studywas conducted in all inpatient departments at Port-Said and Elzohor general hospitals. The sample size was 177 nurses. The study used three instruments: Davidson-Connor resilience Scale, the professional moral courage scale, and the psychological well-being scale. Results: It was evidenced that the majority of nurses have a high level of work resilience (67.8%)' and 50.8% of them have a high level of vocational moral courage, in addition, 62.1% of nurses have a moderate level of psychological well-being. Conclusion: There was strongly a positive statistically significant correlation between the total score of work resilience, vocational moral courage, and psychological well-being. Recommendation Determining factors affecting moral courage, psychological well-being, and resilience, as well as finding strategies and creating an appropriate moral climate can increase nurses' morally courageous behaviors, well-being, and work resilience.