Context: Coffee intake is one of the strategies developed to relief post dural puncture headache (PDPH). It is considered a safe choice for many post-cesarean section women. Aim: This study aimed to examine the effect of coffee intake on post-dural puncture headache parameters among post-cesarean section women. Methods: A quasi-experimental (time series) design was adopted. A convenience sample of 166 post-caesarean section women were recruited. This study was conducted at postpartum department at El-Manial University hospital, Cairo governorate, Egypt. Data were collected using two tools: Structured interview schedule and post-dural puncture headache assessment tool. Results: Concerning incidence of PDPH the study findings revealed that, 71.1%, 53.0%, and 27.7% of the study group suffering from PDPH at first, second, and third evaluation respectively as compared to 100.0%, 96.4%, and 92.8% of the control group. The mean PDPH severity of the study group was documented at 4.4±1.7, 3.1±1.0, and 1.1±0.5 at first, second, and third evaluation respectively while for the control group it was documented at 8.3±2.7, 7.5±2.6, and 6.8±1.5. Regarding analgesic need, it was significantly lower in the study as compared to the control at first, second, and third evaluation (63.6%, 12.7% and 7.2% vs. 86.7%, 61.3% and 56.4% respectively). Conclusion: There were statistically significant differences in favor of the study group compared to the control in relation to three parameters of PDPH i.e., incidence, severity, and analgesics need (p < 0.001). Recommendation: Coffee intake could be used by midwifery nurses as a non-pharmacological method to manage PDPH among post-cesarean section women.