Background: Electronic mind maps are one of the innovative learning approaches that help to improve students, achievement and self-efficacy. Aim: Examine the effect of using electronic mind maps as a teaching strategy on academic vitality, self-efficacy, and achievement among nursing students. Design: A quasi-experimental design with (pretest-posttests, case, and control groups) was utilized to conduct the study. Setting: The current study was conducted at the Faculty of Nursing, Menoufia University, Egypt. Subjects: A convenience sample of 400 new entry students was divided equally into study group and control group. Tools: included (1) Academic vitality questionnaire, (2) Academic Self-Efficacy Scale, (3) Academic achievement questionnaire, and (4) Student Satisfaction Scale. Results: The study revealed that mean scores of academic vitality of electronic mind mapping and conventional groups were 82.85±15.12 & 57.85±18.16 respectively in the post-test. Also, it reported that the mean scores of academic self-efficacy of the electronic mind mapping and conventional groups were175.39±30.97 and 129.76 ±32.21 respectively in the post-test. In addition, the mean scores of academic achievement for the electronic mind mapping and conventional groups are 17.48± 2.76 & 13.98 ± 2.75 respectively in the post-test. In addition, it showed that 86% of the students in the electronic mind-mapping group were satisfied, while only 55% in the conventional group were satisfied. Conclusion: Electronic mind maps are an effective and powerful tool that enhances nursing students, academic vitality, self-efficacy, and achievement Recommendations: Electronic mind maps should be implemented as an acceptable teaching strategy for all courses of nursing students' education.