Background: Premenopause is a significant stage in women's life. Cervical cancer may affect women of all racial and cultural backgrounds. Aim of the study to evaluate effect of Teaching Back Model intervention on premenopausal women's knowledge, attitude and barriers regarding cervical cancer and its screening. Subjects and Methods: At Minia University Hospital for Maternity and Children, a quasi-experimental design (pre-post study) was carried out, convenient sample of 235 premenopausal women who visited inpatient or outpatient clinic for any gynecological issues. Data were gathered using a standardized interviewing questionnaire; comprised series of inquiries about knowledge, attitudes, and barriers pertinent to cervical cancer and its screening. A helpful resource (guide book) was also given to the studied women. Tools of data collection: include Interviewing questionnaire, knowledge, and attitude and barriers assessment tool. Results: the mean age of premenopausal women was 44.12 ± 3.14 years. The study revealed а general increase in knowledge, attitude of the studied women about cervical cancer and reduction of barriers to participate in its screening post-program compared to pre-program; and there was positive relation between total knowledge and attitude scores in post-program all with highly statistically significant differences (p value ≤ 0.001). Conclusion: According to the study's findings, Teaching Back Model intervention considerably enhanced knowledge and attitudes of the majority of premenopausal women. Recommendation: The study can be repeated with a bigger sample size in various locations. In order to develop a tailored educational system and examine the programmers' long-term effects.