The success of scalp cooling in controlling chemotherapy-induced alopecia (CIA) is highly variable between patients receiving chemotherapy regimens, and hair re-growth is often unpredictable and depends on various factors. Aim of this study is to investigate factors influencing the use of scalp cryotherapy to promote hair re-growth in breast cancer patients receiving chemotherapy. Study design: A descriptive explorative design was used to achieve the aim of the current study. Subject: A purposive sampling of fifty adult patients was recruited for the conduction of this study. Setting: The study was conducted in the Hope Cure Oncology Center at Mansoura City. Data collection tools: four tools were used to collect data: 1) Breast cancer patients' Structured Interview Questionnaire, 2) Modified WHO Hair Loss Scale, 3) Hair Re-Growth Scale and 4) Factors influencing Hair Re-Growth with Cryotherapy Questionnaire. Results: There were highly statistically significant differences between age, marital status, disease stage, duration of the disease and number of chemotherapies of the studied patients with relation to factors influencing hair re-growth at (P<0.001). Also, there were statistically significant difference between patients' educational level, living status, cost of treatment, occupation, type of chemotherapy drugs and factors influencing hair regrowth at (P < 0.05). Conclusion: Consistent with study questions, Cryotherapy provides significant successful protection from hair loss during cancer chemotherapy course, and for 2 months after completing the treatment. Recommendations: Further researches should be done to evaluate the effectiveness of scalp Cryotherapy when using the combination chemotherapy with high doses and with more chemotherapeutic cycles.