Intensive care unit psychosis, delirium, is a common disorder among patients in the intensive care units. It is an under-detected problem. Nurses' position at the forefront of patient care requires necessary successful delirium assessment and management. Nurses working with those patients are in challenging and a potentially high stress, which can lead to harmful impacts for those nurses. Resilience is a positive adaptation to nurses' stress management ability and mental wellbeing. The aim of this study is to enhance the nurses' Resilience, knowledge, and perception regarding intensive care unitpsychosis. Design: This study followed a quasi- experimental correlational research design. Setting: It was conducted at intensive care unit located at Kafrelsheikh general hospital. Subject: The subjects of this study included 50 nurses. Tools: Three tools were used to collect data of this study, Tool I: '' Nurses' perception questionnaire regarding delirium'', Tool II; '' Nurses' knowledge questionnaire regarding delirium and its risk factors'', Tool III: The Connor –Davidson Resilience Scale (CD-RISC). Results: The main results revealed that there were marked significant improvement in the studied nurse total scores of resilience, knowledge and perception concerning delirium after implementation of the education program. Also, there were a statistically significant positive correlation between nurses' resilience, knowledge, and perception regarding delirium. Conclusion: the interventional program sessions played a vital role in improvements of nurses' level of resilience, knowledge, and perception toward ICU psychosis. Recommendations: conducting the interventional program as a continuous training for all nurses to achieve more conclusive results.