Background: Hypertension is the main cause of disability and mortality in the world. Although it is a preventable and treatable condition, it can lead to serious and life threatening complications. Therefore, Compliance with antihypertensive treatment and life style modification is very essential. Aim of the study: To evaluate the effect of implementing a tele-nursing versus traditional nursing program on knowledge, life style modification and blood pressure control for hypertensive patients. Study design: A quasi experimental research design was utilized in this study. Setting: This study was carried out at the medical outpatient clinics affiliated to Tanta University Hospitals. Subjects: A purposive sample of 200 hypertensive patients who attended the previous settings, divided into two equal groups. Tools: Three tools were used for data collection. Tool I: Structured questionnaire consisted of three parts. Tool II: The Hill-Bone Compliance Scale. Tool III: Patient's commitment to blood pressure measurement and healthy lifestyle practices, including two parts. Results: there was statistically significant improvement in total knowledge score, commitment to blood pressure measurement, and compliance with healthy life style score in both groups post intervention than before intervention, this improvement was higher among first (tele-nursing) group. Also, there was significant positive correlation between total score of healthy lifestyle practices and total knowledge score for both groups. Conclusion: Tele-nursing method was effective in enhancing patients' knowledge, adherence to antihypertensive medications and lifestyle modification for better control of blood pressure. Recommendations: The health policymakers should consider tele-nursing in actively managing hypertensive patients in all health settings.