Job satisfaction relates to nurses' health, productivity, job performance and quality of patients care. A better understanding of the determinants of job satisfaction among mental health nurses may allow identification of strategies to improve the working conditions for these nurses with resulting benefits for the quality of nursing care. Aim of the study: Examine the role of both moral distress and sense of coherence on job satisfaction among nurses working with patients having psychiatric disorders. Study Design: A descriptive correlational design. Setting: The research was done at the Mental Health Hospital and Addiction in Benha City, Qalyubia Governorate and Tanta Mental Health Hospital in Tanta City, Gharbia governorate which both are affiliated to General Secretariat of Mental Health in Egypt. Subjects: Convenience sample of 200 nurses from the previous study settings. Tools for Data Collection: Four tools were used, Socio-demographic and Professional Data Structured Questionnaire, Moral Distress Scale Psychiatry (MDS-P), Sense of Coherence Scale (SOC) and Job Satisfaction Scale. Results: More than half of studied nurses have moderate level of moral distress, more than three quarters of studied nurses had moderate level of sense of coherence and most of the studied nurse had semi satisfactory job and results revealed that both moral distress and sense of coherence had a statistically significant prediction role on job satisfaction. Conclusion and Recommendations: The study indicated that moral distress and sense of coherence are dominant factors in job satisfaction and play a role in psychiatric nurses' job satisfaction and study recommended that moral empowerment program and sense of coherence enhancement program are recommended for nurses working with patients having mental disorders.