Background: In providing care for psychiatric patients, caregivers play a critical role. Increased caregiver's burden may increase their susceptibility to mental disorders and demonstrate submissive behavioral patterns, which are one of the least efficient coping strategies and may have a mediating effect on future depression. Aim: A study designed for exploring the relation between the burden of caregiving, submissive behaviors, and depressive symptoms among caregivers of psychiatric patients. Subjects and Method: The study used a descriptive correlational research design. 148 caregivers of psychiatric patients at the time of the visit from the inpatient department and also from the outpatient clinics in Port-Said Psychiatric Health Hospital were included in the study. To gather the necessary data, three instruments were used. Instrument I: Zairt Care Giver Burden Scale, Instrument II: Submissive Acts Scale, Instrument III: Beck Depression Inventory, additionally, personal and clinical data questionnaire. Results: According to the findings, the majority of psychiatric patients' caregivers had a severe level of burden, more than half of them had a high level of submissive behavior, and almost all of them had a severe level of depression. Conclusion: A statistically significant positive correlation was found between caregiving burden, submissive behaviors, and depressive symptoms among the studied caregivers of psychiatric patients at p ≤ 0.05. Recommendations: Appropriate interventions could reduce the burden on caregivers and teach effective coping approaches which had a beneficial impact on depressive symptoms among caregivers of psychiatric patients.