Background: Pregnant women's fear and anxiety about COVID-19 are increasing which reducing the social performance and quality of life. Aim: explore the relation between psychological problems, fear and anxiety, with COVID-19 pandemic and the quality of life among pregnant women. Design: Descriptive research design. Setting: The study carried out in the antenatal out-patients clinic at Women' Health Hospital, Assiut University. Sample: Included 350 pregnant women. Tools: Four tools were used; Tool (1): Structured interviewing questionnaire, Tool (2): Fear of COVID-19 Scale (FCV-19S). Tool (3): COVID-19 Anxiety Scale (CAS) and Tool (4): Pregnant women's quality of life questionnaire. Results: 55.4% and 45.7% of mothers aged 25-30years and had secondary education respectively. 45.4% of them had low fear level of COVID 19. While, 26.9% of the pregnant women; were had high anxiety level. Conclusion: There were positive correlation between fear and anxiety about COVID 19 and pregnant women quality of life. There were statistical significance differences between pregnant women educational level, occupation, residence and gestational age with their quality of life. Recommendations: Further researches should be conducted to implement intervention program to alleviate the level of fear and anxiety about COVID-19 to improve pregnant women quality of life.