The Chronic obstructive pulmonary disease (COPD) is a chronic disorder affecting the lung efficiency and causing respiratory disturbances as shortness of breath, cough. It highly combined with psychological distress and numerous sleeping disturbances. Aim: The aim was to assess the quality of sleeping among Patients with Chronic Obstructive Pulmonary Disease. Setting sample: Purposeful sample composed of 185 patients selected from the outpatient Clinics at Kafrelsheikh Chest Hospital. Tool: 1st Tool: interview questionnaire tool, This tool was 3 main parts: Part 1: personal demographic profile, Part 2: Medical data sheet, Part 3: Physical examination sheet. 2nd Tool: The Pittsburgh Sleep Quality Index (PSQI). 3rd tool: Assess factors affecting the sleep quality. 4th Tool: Depression, Anxiety and Stress Scale (DASS-21). Results: The results revealed that 71.4% of the study were male, 76.8% had unsatisfactory quality of sleep, 48.1% of patients' sleep was affected by daily life habits 68.6% of the patients had extremely severe level of stress. There were statistically significant associations between quality of sleep and Physiological factors, Environmental factors, Meals, Daily Life Habits. Statistically significant correlation between quality of sleep, and their anxiety, stress, and depression level was revealed. Conclusion: The majority of patients with COPD had an unsatisfactory level of sleep. There was a highly statistically significant difference between quality of sleep score and factors affecting sleeping, physical examination, and psychological distress. Recommendations Conduct educational programs for patients with COPD to improve their quality of sleeping, physiological changes, factors enhance sleeping and psychological distress related to disease.