Background: Polycystic ovary syndrome is most common female endocrine disorder which cause distress in both physical and emotional well-being and leads to long life suffering of the affected female, so the aim of this study is to assess impact of lifestyle changes intervention on quality of life and self -esteem of adolescent female with polycystic ovary syndrome. Methods: Predictive correlation research design was used. A purposive sample of 50 females with PCOS were included. Pre/post intervention subject's assessment was done. The intervention was administered in five sessions. Quality of life, self f-esteem were measured pre and post intervention. Results: Subjects' knowledge regarding poly cystic ovary was improved significantly post the intervention, also incidence of obesity among subjects' decreased by 16% compared with 66% pre intervention. Regarding subjects' self-esteem 96% of the subjects had low self-esteem before the intervention, compared to 30 percent after 6 months and just 20% after 12 months. There were also significant variations in physical, psychological, and social domains of quality of life pre and post the intervention. Conclusion: The lifestyle modifications have a positive effect on the quality of life and self-esteem of the study participants. Recommendation: Lifestyle changes are the starting point for PCOS adolescent females to enhance their awareness, quality of life, and self-esteem, as well as sustain their therapeutic plan compliance, and they need long-term follow-up, as well as their ability to cope with PCOS and overall life satisfaction.