Aphrodisiacs in recent years have become popular with the increased prevalence of sexual problems worldwide. Aim: Determine the prevalence of aphrodisiac drugs consumption and its associated factors among the married men. Design: cross sectional design was used. Setting: Beni-Suef city. Sample: convenient sample to select 380 subjects. Tools of data collection: two tools were used; the first was a questionnaire composed of 6 parts to assess socio-demographic data, medical history, and pattern of aphrodisiac use, knowledge regarding aphrodisiac drugs, life style and erectile dysfunction, the second tool was the perceived stress scale. Results: the data revealed that 38.2% of the studied sample reported using the aphrodisiac drugs and 85.5% of them used the aphrodisiac drugs without doctor order. The data added that 45.2% have high perceived stress, 24.2 % had mild erectile dysfunction, 49.7% had unsatisfactory level of knowledge and 42.1% reported unhealthy life style. The consumption of aphrodisiac drugs was significantly associated with age, educational level, having multiple wives, level of erectile dysfunction, levels of perceived stress, level of knowledge and life style of the studied sample where P is <0.05. Conclusion: Results of the study concluded that 38.2% of the participants reported using the aphrodisiac drugs and was influenced by the socio-demographic data, level of erectile dysfunction, levels of perceived stress, level of knowledge and life style of the studied sample. Recommendation: Health education programs to improve the population awareness about sexual health and the negative consequences of self-prescribing aphrodisiac drugs.