Background: COVID-19 is a pandemic disease begins on 11March, 2020; it was growing internationally. Pregnancy suppresses the immune system, making pregnant women more vulnerable to COVID-19 infection and severe sickness. To avoid becoming infected with the virus, extreme awareness is advised. Knowledge of the condition and one's attitude toward it both play a role in one's willingness to embrace public health interventions. Aim: Was to assess the knowledge, attitude and practice toward corona virus infection among pregnant women attending antenatal care clinics at Kafrelsheikh Hospitals, Egypt. Subjects and method: Design: Descriptive research design was utilized in this study. This study was conducted at antenatal care Clinics at Kafrelsheikh General and University Hospitals, Egypt. Subjects: A convenient sample of 415 pregnant was included in this study. Tools: The data were collected using four tools. Tool 1: Socio-demographic structured interview schedule Tool II: The pregnant woman's knowledge about COVID-19 infection assessment questionnaire. Tool III: The pregnant woman's attitude toward COVID-19 infection assessment questionnaire. Tool IV: The pregnant woman's practice of COVID-19 preventive measures questionnaire: Results: According to current study, more than two-thirds (75.4 percent; 95 percent and 43.6 percent of pregnant women respectively) had good knowledge, positive attitude, and excellent practice concerning the coronavirus pandemic. Studied women according to the factors related to their knowledge of coronavirus infection 2.99 revealed that, (1.7–5.0) and 1.6 (1.2–2.7) respectively were found to be more likely to have good knowledge among pregnant women who had completed secondary school or above and lived in urban area. AOR = 1.7 (1.2–2.6) and 2.3 (1.3–4.0) respectively for good practice of preventive measures were maternal age of 25 years and being an urban resident. Conclusion: The target population had good knowledge, excellent practice, and positive attitude towards COVID-19. Recommendations: Pregnant women from isolated areas as well as those with lower levels of education should be educated, and legal enforcement should be established to improve the implementation of covid-19 preventive measures