Background: Today, Coronavirus diseases 2019 impose an important occupational risk to health care workers (HWs). Until now, globally several thousand of HWs especially nurses have been infected with severe acute respiratory syndrome coronavirus. Aim: to identify the epidemiological features, coping strategies of infection and investigate the extent of reinfection with COVID- 19 virus among nurses working in tertiary care hospitals. Subjects and Method: -Study design: In this study, a descriptive cross-sectional research design was used. Study settings: The study was carried out in Tanta University hospitals, El-Gharbeya Governorate. Tools of data collection: - Two tools were used for data collection: A structured questionnaire sheet, and coping strategies questionnaire. Results: there were statistically significant relations between all items of socio-demographic criteria of the studied nurses and occurrence of COVID-19 reinfection where P