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246586

Exercise Limitation in Children after Tetralogy of Fallot Repair Is Not related to Right Ventricular Dysfunction: Single Egyptian Center Experience

Article

Last updated: 22 Jan 2023

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Abstract

Background: Tetralogy of Fallot (TOF) is one of the most prevalent cyanotic congenital heart diseases requiring surgery early in life.
Aim of work: Exercise capacity and right ventricular diastolic dysfunction in children after TOF repair.
Methods: Cross sectional descriptive study was conducted on 27 cases with TOF after total surgical repair. Cases were subjected to 12 leads ECG, chest X-ray, 6-minute walking test (6MWT) to assess the exercise capacity and transthoracic color Doppler echocardiography with assessment of right ventricle myocardial performance index (RVMPI) and pulmonary regurgitation index (PRi).
Results: The mean ± SD age  of the our studied was TOF patients 6.59 ± 1.80 years. The mean ± SD age at operation was 2.46 ± 0.95 years. All  had dilated right ventricle (right ventricle dilatation index RVDi > 0.5), and moderate to severe pulmonary regurge (PR) estimated by PRi (PRi <0.77). Impaired RVMPI (>0.32) was found in 6 (22%) patients. Exercise capacity measured by 6-MWT was significantly reduced compared to the normal population of the same age group (p= 0.001). Results of 6-MWT did not correlate with the RVMPI (p= 0.44, r= -0.077),  the PRi (p= 0.83, r=0.006),  QRS (p=0.31, r=0.066), or corrected QT interval (p=0.89, r= 0.169).
Conclusion: Exercise capacity was limited in our TOF patients after surgical repair, that was not related to right ventricular diastolic dysfunction as it did not correlate with RVMPI, degree of PR, QRS duration, nor corrected QT interval.

DOI

10.21608/cupsj.2022.140060.1052

Keywords

Tetralogy of Fallot (TOF), Right ventricular dysfunction, Exercise capacity, 6-minute walking test, children

Authors

First Name

Lamiaa Abdelrahman

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

dr.lamiaa@me.com

City

giza

Orcid

0000-0003-1365-5463

First Name

Fatma Al Zahraa

Last Name

Mostafa

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

fatmaalzahraah@hotmail.com

City

-

Orcid

0000-0002-9624-2375

First Name

Gehan

Last Name

Hussein Ahmed

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

gehanha@hotmail.com

City

-

Orcid

0000-0002-8686-8032

First Name

Mohamed

Last Name

Abd El Rahman

MiddleName

-

Affiliation

Department of Pediatric Cardiology, Saarland University Hospital, Homberg, Germany

Email

mohamed.abd-el-rahman@uks.eu

City

saar, germany

Orcid

-

First Name

Sherif

Last Name

Elmahdy

MiddleName

-

Affiliation

Department of Pediatrics, Om Alatiba Hospital, Cairo, Egypt

Email

sherifelmhdy@yahoo.com

City

-

Orcid

-

First Name

Hanan

Last Name

Khaled

MiddleName

Z.

Affiliation

Department of Pediatrics, Faculty of medicine, Cairo University

Email

dr.hananzekri@gmail.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

35212

Issue Date

2022-07-01

Receive Date

2022-05-22

Publish Date

2022-07-01

Page Start

203

Page End

209

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 2_Pages 203-209.pdf

PDF . 709.8kB

Link

https://cupsj.journals.ekb.eg/article_246586.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=246586

Order

11

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023