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245869

Activin A is Not a Reliable Prognostic Biomarker For Bilirubin Induced Neurotoxicity in Neonates

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Last updated: 22 Jan 2023

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Abstract

Background: Bilirubin induced neurological dysfunction (BIND) remains an important cause of disability in developing countries. Although high total serum bilirubin (TSB) is the main instigator for BIND, different babies may have different neurological outcomes at the same TSB level. This reflects the need for a more specific predictive factor for the neurological outcome, which would allow prompt intervention and prevention of kernicterus. 
Aim of the Work: To assess the value of serum activin A as a predictor for acute bilirubin neurotoxicity and adverse neurodevelopmental outcomes at one year of life.
Materials and Methods: The study enrolled 84 term/near-term infants admitted with indirect hyperbilirubinemia requiring intervention to the Neonatal Intensive Care Unit of Cairo University Children's Hospital. Clinical examination, BIND score and laboratory tests including activin A were performed. Neurodevelopmental outcome was assessed at 3, 6 and 12 months using the Bayley scale of Infant Development II. Correlations between serum activin A, TSB, BIND scores and Bayley scores were studied.
Results: Mean TSB level at admission was 25.92±7.14 mg/dL. BIND score at admission ranged from 0-7, and mean serum activin A level was 109.92±55 pg/ml. Activin A did not show significant correlations with TSB or BIND scores.  A negative correlation between activin A level and psychomotor developmental index (PDI) at 3 months was detected however all other neurodevelopmental outcomes showed no significant correlation with activin A.
Conclusion: In cases of neonatal hyperbilirubinemia, activin A is not a reliable biomarker for predicting acute or chronic bilirubin induced neurotoxicity.

DOI

10.21608/cupsj.2022.245869

Keywords

Hyperbilirubinemia, Bilirubin, BIND score, Acute bilirubin encephalopathy, Bayley scales of infant development, Activin A

Authors

First Name

Esraa

Last Name

Elmazzahy

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

dresraaelmazahy@cu.edu.eg

City

Giza

Orcid

0000000204362338

First Name

Iman

Last Name

Iskander

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

iman.iskander@kasralainy.edu.eg

City

Cairo

Orcid

-

First Name

Hazem

Last Name

Abou-Youssef

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

hazem2000@kasralainy.edu.eg

City

Cairo

Orcid

0000-0001—5088-5909

First Name

Hanan

Last Name

Madani

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt

Email

hanan.madani@kasralainy.edu.eg

City

Cairo

Orcid

0000-0002-4705-0828

First Name

Sarah

Last Name

ElTatawy

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

statawy@cu.edu.eg

City

Cairo

Orcid

0000-0002-5131-5788

Volume

2

Article Issue

2

Related Issue

35212

Issue Date

2022-07-01

Receive Date

2022-06-04

Publish Date

2022-07-01

Page Start

139

Page End

146

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 2_Pages 139-146.pdf

PDF . 944.3kB

Link

https://cupsj.journals.ekb.eg/article_245869.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=245869

Order

4

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

-

Details

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Article

Created At

22 Jan 2023