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210823

Hepatitis Post Cardiopulmonary Bypass in Children: Single Center Experience in Egypt

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Last updated: 04 Jan 2025

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Abstract

Background: Cardiopulmonary surgery is associated with risk of liver dysfunction due to hypoperfusion, release of mediators by macrophages and drug induced liver injury.
Aim of the work: to assess liver functions and sonographic changes post- cardiopulmonary bypass in children. 
Methods: Fifty children with congenital heart diseases who underwent cardiac surgery were assessed. Liver function tests, abdominal ultrasound and echocardiography were performed for those with impaired liver functions at 6 months and up to 18months postoperatively.
Results: Among 50 studied children (30 males and 20 females); 40 underwent cardiopulmonary bypass (CPB) and 10 underwent closed heart surgery. Twelve (24%) patients had elevated liver transaminases (aspartate transaminase (AST) and alanine transaminase (ALT)). They all proved to have anti-hepatitis C virus (HCV) antibodies and positive HCV by polymerase chain reaction (PCR). Brightness of liver (20 cases), hepatomegaly (12 cases) and congested hepatic veins (10 cases) were the most important sonographic findings. Significant relation was found between elevated liver enzymes and HCV (p=0.012). There was no correlation between CPB or congenital structural defect or surgical procedure and hepatic affection (p>0.05).
Conclusion: Open heart surgery may be associated with increased risk of hepatitis C infection. Increased liver brightness is the most common sonographic finding. Pre-cardiac surgery screening for HCV is mandatory in children. 

DOI

10.21608/cupsj.2021.95136.1027

Keywords

Cardiopulmonary bypass, Liver Function Test, congenital heart diseases, Hepatitis C virus, HCV

Authors

First Name

Magd

Last Name

Kotb

MiddleName

Ahmed

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

magdkotb@kasralainy.edu.eg

City

-

Orcid

https://orcid.org/00

First Name

Fatma Al Zahraa

Last Name

Mostafa

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

fatmaalzahraah@hotmail.com

City

-

Orcid

0000-0002-9624-2375

First Name

Mohamed

Last Name

Khalil

MiddleName

-

Affiliation

Department of Cardiac Surgery, Faculty of Medicine, Cairo University, Egypt

Email

dr_mohamed_khalil@cu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdelraouf

MiddleName

Mohamed

Affiliation

Department of Cardiac Surgery, Faculty of Medicine, Cairo University, Egypt

Email

mohamedraouf2@gmail.com

City

-

Orcid

-

First Name

Lobna

Last Name

Ammar

MiddleName

-

Affiliation

Department of Pediatrics, Kalyoob Specialized Hospital, Egypt

Email

lobnaammar@gmail.com

City

-

Orcid

-

First Name

Nahla

Last Name

Sabry

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

nahla595@gmail.com

City

-

Orcid

0000-0003-2165-3986

Volume

2

Article Issue

1

Related Issue

29646

Issue Date

2022-01-01

Receive Date

2021-09-09

Publish Date

2022-01-01

Page Start

82

Page End

88

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 1_Pages 82-88.pdf

PDF . 719.2kB

Link

https://cupsj.journals.ekb.eg/article_210823.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=210823

Order

11

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

Hepatitis Post Cardiopulmonary Bypass in Children: Single Center Experience in Egypt

Details

Type

Article

Created At

22 Jan 2023