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210818

Glycemic Control in Adolescent Girls with Type 1 Diabetes Mellitus

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Last updated: 22 Jan 2023

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Abstract

Background: Optimal glycemic control is essential during type 1 diabetes (T1D) management to minimize the occurrence of both short and long term complications. Many factors might influence diabetes control including puberty which is a challenging period. 
Aim of the work: To assess the effect of puberty on glycemic control in adolescent females with T1D and to compare glucose levels, insulin demand and carbohydrate intake in the week of menstruation to those in the luteal phase. 
Methods: This cross-sectional, pilot study took place in the Diabetes, Endocrine and Metabolism Pediatric Unit, Cairo University Children's Hospital, Egypt. It included 30 prepubertal Tanner stage 1 girls (Group-1) and 30 full pubertal girls Tanner stage 5 (Group 2) with regular menstruation were included in the study. Mean blood glucose levels, insulin doses and glycated hemoglobin(HbA1C) (average of the last 4 readings over 1 year) were compared. 
Results: Ages of enrolled girls ranged from 10-15 years (group 1: mean age ± SD=11.67±1.33; group 2: 13.93±.0.94; p < 0.001 ) with T1D durations of 5.12-5.42 years. Mean HbA1c and insulin doses were similar in both pubertal and prepubertal girls after adjusting data for BMI SDS and participation in exercise (p=0.164 and 0.157 respectively). Mean blood glucose levels, insulin doses and carbohydrate intake were significantly higher (by 8%, 18% and 7.5% respectively) during menstruation (early follicular) than in the luteal phase (p < 0.001). 
Conclusion: Glycemic control in pubertal females with T1D was challenged by the higher BMI, lack of activity and growth spurt that characterize this stage of development. Contrary to some other studies, among our studied cohort glycemic control also exhibited deterioration in the early follicular phase that was associated with greater carbohydrate consumption compared to the luteal phase. 

DOI

10.21608/cupsj.2021.99617.1030

Keywords

type 1 diabetes mellitus, Glycemic control, Menstruation, Insulin Resistance, Luteal phase

Authors

First Name

Yomna

Last Name

Shaalan

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

yomnamshaalan@gmail.com

City

Cairo

Orcid

0000-0003-0931-4092

First Name

Nora

Last Name

Badawi

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

nora.badawi@kasralainy.edu.eg

City

Cairo

Orcid

0000-0002-2037-6844

First Name

Aliaa

Last Name

Soliman

MiddleName

-

Affiliation

The Pediatric Intensive Care Unit, El Galaa Hospital, Cairo, Egypt

Email

aliaasoliman5@gmail.com

City

-

Orcid

0000-0002-8161-8528

First Name

Abdelkarim

Last Name

Kamel

MiddleName

-

Affiliation

The Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Egypt

Email

abdelkarim.kamel@kasralainy.edu.eg

City

-

Orcid

0000-0003-2881-6530

First Name

Marise

Last Name

Abdou

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

marisemd80@gmail.com

City

Cairo

Orcid

0000-0001-9961-5299

Volume

2

Article Issue

1

Related Issue

29646

Issue Date

2022-01-01

Receive Date

2021-10-05

Publish Date

2022-01-01

Page Start

39

Page End

45

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 1_Pages 39-45.pdf

PDF . 698.7kB

Link

https://cupsj.journals.ekb.eg/article_210818.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=210818

Order

6

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

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Details

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Article

Created At

22 Jan 2023