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210816

Vitamin D Level and Disease Activity in Children with Juvenile Idiopathic Arthritis

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Last updated: 04 Jan 2025

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Abstract

Background: Vitamin D deficiency is thought to aggravate juvenile idiopathic arthritis (JIA) activity. 
Aim of the work: To assess serum 25-hydroxy vitamin D [25(OH) D] level in Egyptian children with JIA and correlate its level with subtypes of JIA and disease activity scoring.
Methods: This was a cross-sectional study that included 70 children with JIA of one year or less disease duration and 40 apparently healthy control children. Disease activity was measured using Disease Activity Score in 28 joints (DAS28) for polyarticular and oligoarticular JIA. Serum 25-hydroxyvitamin D [25(OH) D] was measured using Enzyme Linked Immuno- Sorbent Assay technique. 
Results: Serum 25 (OH) D was significantly lower in JIA patients (mean ±SD= 17.32± 9.7  ng/mL) than in the control group (mean ± SD= 27.9± 7.4 ng/mL) (p-value =0.001). Serum 25(OH) D levels correlated inversely with the number of affected joints (r= - 0.122, p =0.316). Another inverse correlation with severity score was noted (r= - 0.2, p=0.098) but it was not statistically significant. It did not correlate with age at onset of disease (r=-0.2, p=0.096) or gender (r=-0.105, p=0.387) or duration of disease (r=-0.038, p=0.754).
Conclusion: Serum levels of 25(OH) D were lower in patients with JIA disease. Serum vitamin D levels inversely correlated with number of affected joints, but not severity of JIA. Larger studies are needed to confirm the relation between vitamin D and JIA disease activity.

DOI

10.21608/cupsj.2021.81751.1023

Keywords

disease activity, Egyptian children, Juvenile idiopathic arthritis, Vitamin D, [25 (OH) D]

Authors

First Name

Emad

Last Name

Ghobrial

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

dr.emademil@yahoo.com

City

Cairo

Orcid

-

First Name

Huda

Last Name

Marzouk

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

nourelhudaahmedyousef@yahoo.com

City

-

Orcid

0000-0003-3832-4417

First Name

Mervat

Last Name

Khorshied

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt

Email

mervatkhorshied@hotmail.com

City

Cairo

Orcid

-

First Name

Eman

Last Name

Gado

MiddleName

-

Affiliation

Ministry of Health and Population, Cairo, Egypt

Email

eman_gado85@yahoo.com

City

Cairo

Orcid

-

Volume

2

Article Issue

1

Related Issue

29646

Issue Date

2022-01-01

Receive Date

2021-06-21

Publish Date

2022-01-01

Page Start

25

Page End

31

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 1_Pages 25-31.pdf

PDF . 906.5kB

Link

https://cupsj.journals.ekb.eg/article_210816.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=210816

Order

4

Type

Review Article

Type Code

1,276

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

Vitamin D Level and Disease Activity in Children with Juvenile Idiopathic Arthritis

Details

Type

Article

Created At

22 Jan 2023