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210815

Zinc Supplementation Improves Nocturnal Asthma Symptoms

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Last updated: 22 Jan 2023

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Abstract

Background: Treatment of bronchial asthma aims to control the symptoms of bronchoconstriction and disease modification. Zinc influences bradykinin that promotes inflammation and promotes contraction of  smooth muscle in the bronchus.
Aim of the work: To test the effect of zinc supplementation on improvement of both clinical symptoms and lung functions in children with bronchial asthma. 
Methods: Asthma symptoms, severity and pulmonary function tests were performed to 50 children with bronchial asthma before and after zinc supplementation (1mg/kg/ day) as adjuvant therapy. Serum zinc levels were assessed at initial enrollment for all 50 children. 
Results: The studied cohort comprised 28 boys and 22 girls with age range of 6-13 years and mean age +/- SD of 8.88 +/- 2.24 years. Of them 48 %, 30 % and 22% were diagnosed: moderate persistent asthma, mild persistent and severe persistent asthma respectively. Initial serum zinc level was low in 34% of patients (mean 47.2 ±10.8 µg/dl) and 66% of patients had a normal initial serum zinc level (mean 100.6 ± 27.2 µg/dl). After 8 weeks of zinc supplementation there was a significant improvement in decreasing frequency of attacks (p=0.036), nocturnal symptoms (p < /span>˂ 0.001), clinical control of asthma symptoms (p < /span>˂ 0.001) and pulmonary functions showed significant improvement in forced expiratory volume in 1 second (FEV1) (p < /span>˂0.001) and forced vital capacity (FVC) (p=0.002) but there was no significant difference in the frequency of daytime symptoms (p < /span>˃0.05), limitation of activities (p < /span>˃0.05) or need for reliever medications (p < /span>˃0.05). 
Conclusion: Zinc is an effective adjuvant in controlling nocturnal symptoms and  significantly improves pulmonary functions even if the initial serum zinc level was within the normal range.

DOI

10.21608/cupsj.2021.107314.1038

Keywords

bronchial asthma, symptoms, Nocturnal, Zinc sulfate

Authors

First Name

Iman

Last Name

Abdelaziz

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

iman.omar@kasralainy.edu.eg

City

Cairo

Orcid

0000-0001-5753-718

First Name

Magd

Last Name

Kotb

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

magdkotb@hotmail.com

City

Cairo

Orcid

0000-0003-2118-3793

First Name

Noha

Last Name

Yassin

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

noha.adel20@yahoo.com

City

-

Orcid

0000-0002-9297-4990

First Name

Walaa

Last Name

Rabie

MiddleName

-

Affiliation

Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University

Email

wl.rabie@kasralainy.edu.eg

City

Cairo

Orcid

0000-0001-6197-3648

First Name

Alsayed

Last Name

Alsayed

MiddleName

-

Affiliation

Pediatrics Department, Ashmoun Hospital, Menofeya, Egypt

Email

alsayed.fathy86@gmail.com

City

Menofeya

Orcid

-

First Name

Dina

Last Name

Hamed

MiddleName

-

Affiliation

Pediatrics Department, Faculty of Medicine, Cairo University, Egypt

Email

dinahossam@yahoo.com

City

Cairo

Orcid

0000-0002-6927-5294

Volume

2

Article Issue

1

Related Issue

29646

Issue Date

2022-01-01

Receive Date

2021-11-22

Publish Date

2022-01-01

Page Start

10

Page End

16

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 2_Issue 1_Pages 10-16.pdf

PDF . 708.9kB

Link

https://cupsj.journals.ekb.eg/article_210815.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=210815

Order

2

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

-

Details

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Article

Created At

22 Jan 2023