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179785

Nasopharyngeal Microbiome Composition is Different Among Children with Bronchial Asthma

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Last updated: 04 Jan 2025

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Abstract

Background: The microbiome composition is as unique and diverse as humans are; it may vary substantially over time. A stable microbiome is essential for immune development, while dysbiosis in the microbiome has been associated with an increased risk for asthma and allergies. Knowledge about nasopharyngeal microbiome among Egyptian children with asthma is lacking. 
Aim of the work: To study the nasopharyngeal microbiome in a group of Egyptian asthmatic children, and to compare it to a group of healthy controls of similar age and sex distribution.
Subjects and Methods: A cross-sectional case-control study was performed on 60 Egyptian children aged 1-13 years. Of those, 30 children suffered un-exacerbated asthma, and 30 children were healthy controls. Nasopharyngeal swabs were obtained from all participants and the nasopharyngeal microbiome was identified using the VITEK 2 system after primary organism isolation by routine cultures. 
Results: A statistically significant difference was found for the overall microbiome composition between asthmatic and control children (p=0.007). The most common combination of organisms in asthmatics was Staphylococcus aureus and Streptococcus pneumoniae, and was statistically higher than in controls (0.038). Normal controls had a higher incidence of presence of coagulase negative staphylococci (30%) than the asthmatic group (3.3%) (p-0.009). Kocuria rosea, although present more in asthmatics, the difference did not reach statistical significance. However, within the asthmatic group, the presence of K. rosea was noted more in patients with more severe asthma (p=0.02).
Conclusion: The microbiome composition in a group of asthmatic Egyptian children was different from that of healthy controls. Whether this difference has a causative relation to asthma development /severity, or is due to upregulation of certain species to combat certain environmental hazards was beyond the scope of this study and awaits further research.

DOI

10.21608/cupsj.2021.75415.1019

Keywords

Asthma, children, Microbiome, nasopharyngeal

Authors

First Name

Christine

Last Name

Basanti

MiddleName

W.S.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Email

christine.w.shaker@gmail.com

City

-

Orcid

0000-0002-3149-9233

First Name

Magd

Last Name

Kotb

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Email

magdkotb@kasralainy.edu.eg

City

-

Orcid

https://orcid.org/00

First Name

Amal

Last Name

Sayed

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.

Email

aml.said@kasralainy.edu.eg

City

cairo

Orcid

-

First Name

May

Last Name

Abdelfattah

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Email

mayabdelfattah@kasralainy.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Ghanem

MiddleName

-

Affiliation

Department of Pediatrics, Al Anfoshy General Hospital, Alexandria, Egypt.

Email

dr.mohamed.ghanem88@gmail.com

City

-

Orcid

-

First Name

Azza

Last Name

Abdelmegeid

MiddleName

K.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt.

Email

azzakamal1718@gmail.com

City

-

Orcid

0000-0002-6665-3771

Volume

1

Article Issue

2

Related Issue

25899

Issue Date

2021-07-01

Receive Date

2021-05-06

Publish Date

2021-07-01

Page Start

77

Page End

88

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 1_Issue 2_Pages 77-88.pdf

PDF . 885.9kB

Link

https://cupsj.journals.ekb.eg/article_179785.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=179785

Order

4

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

Nasopharyngeal Microbiome Composition is Different Among Children with Bronchial Asthma

Details

Type

Article

Created At

22 Jan 2023