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179782

Function Heterogeneity of Different Segments of Left Ventricle in Pediatric Dilated Cardiomyopathy: A Tissue Doppler Study

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Last updated: 22 Jan 2023

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Abstract

Background: Dilated cardiomyopathy (DCM) is characterized by impaired systolic and diastolic function of one or both ventricles. Aim of the Work: To assess left ventricular (LV) regional systolic as well as global systolic, diastolic functions and desynchrony in children with idiopathic DCM using tissue Doppler imaging. Materials and Methods: The study comprised 30 patients with idiopathic DCM (4.4±3.3 years) and 10 healthy children as a control group. Electrocardiography (ECG)-gated echocardiography was done using m-mode and conventional Doppler as well as tissue Doppler imaging to obtain modified Tei index, mitral annular wave velocities (S', E' and A') as well as offline analysis of color tissue velocity imaging to obtain the peak systolic velocities of 12 LV points in apical four chamber, two chamber and long axis views.  Results: The peak systolic velocities of mitral annulus as well as the different LV segments of patients were significantly lower than that of the control group. The E/E' ratio of patients was (11.39+2.4). S' and E' wave of lateral and septal aspects of mitral annulus were correlated. The Tei index of LV of patients (0.568±0.1136) was significantly higher than that of the control group. The averaged mid LV segments showed significantly lower peak systolic velocity (3.018±0.777cm/sec). There was significant difference between different LV segments as regards the peak systolic velocities (P<0.05). When comparing the time to peak standard deviation (TP-SD) of lateral wall (±36.071) to septal wall (±33.020), no marked difference was detected (P>0.05).  Conclusion: The diastolic dysfunction among children with idiopathic DCM lies in the borderline zone. Systolic and diastolic dysfunctions correlate. There is regional heterogeneity of left ventricular systolic velocities being in general lower in mid segments. No marked left ventricular systolic desynchrony in DCM was found in pediatric age group. 

DOI

10.21608/cupsj.2021.61692.1012

Keywords

dilated cardiomyopathy, Systolic dysfunction, Diastolic Dysfunction, Tissue Doppler imaging, Left ventricular segments, desynchrony

Authors

First Name

Yasser

Last Name

Sedky

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

ymsedky@hotmail.com

City

Cairo

Orcid

-

First Name

Sonia

Last Name

El-Saiedi

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

myheartclinic@windowslive.com

City

Cairo

Orcid

0000-0001-6992-4242

First Name

Nevine

Last Name

Habeeb

MiddleName

M.M.

Affiliation

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt

Email

nevin.habib@yahoo.com

City

Giza

Orcid

-

First Name

Rania

Last Name

El Kaffas

MiddleName

M.H.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

raniaelkaffas@yahoo.com

City

Giza

Orcid

-

First Name

Mona

Last Name

Gabre

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

drmonaahmed11@yahoo.com

City

Giza

Orcid

-

First Name

Ahmad

Last Name

Badr

MiddleName

M.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

abadr2007@yahoo.com

City

Giza

Orcid

-

First Name

Mohamed

Last Name

Eid

MiddleName

S.

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

mohamed_samir_eid@cu.edu.eg

City

Giza

Orcid

0000-0003-4245-7482

Volume

1

Article Issue

2

Related Issue

25899

Issue Date

2021-07-01

Receive Date

2021-02-08

Publish Date

2021-07-01

Page Start

52

Page End

61

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 1_Issue 2_Pages 52-61.pdf

PDF . 1.1MB

Link

https://cupsj.journals.ekb.eg/article_179782.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=179782

Order

1

Type

Original Research

Type Code

1,229

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023