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132215

Clinical Spectrum and Challenges of Primary Immunodeficiency disorders in Egyptian children

Article

Last updated: 22 Jan 2023

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Abstract

Primary Immunodeficiency Disorders (PID) are inherent defects of the immune system that may present in infants and children. The main presentations include increased susceptibility to infections (a narrow or broad spectrum of pathogens), autoimmunity, autoinflammation, allergy and/or malignancy. PIDs are increasingly diagnosed and may present with different phenotypes that range from subtle to severe ones. They are classified into ten major categories according to the International Union of Immunological Societies (IUIS). Autosomal recessive disorders are noticeably more common because of the high consanguinity rates in the society. The spectrum of PID is highlighted with a brief walk through the challenges of establishing a PID service in a resource limited setting like catching up with the rapidly changing field, provision of state of the art diagnostic services and actual provision of medical care to PID patients. Several opportunities for growth of the field and overcoming obstacles are discussed.

DOI

10.21608/cupsj.2020.45178.1005

Keywords

Primary immunodeficiency disorders, Recurrent Infections, Spectrum

Authors

First Name

Nermeen

Last Name

Galal

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt

Email

nermeengalal@gmail.com

City

Cairo

Orcid

0000-0002-6595-3641

Volume

1

Article Issue

1

Related Issue

19715

Issue Date

2021-01-01

Receive Date

2020-10-05

Publish Date

2021-01-01

Page Start

7

Page End

10

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 1_Issue 1_Pages 7-10.pdf

PDF . 536.1kB

Link

https://cupsj.journals.ekb.eg/article_132215.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=132215

Order

2

Type

Communication

Type Code

1,631

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

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Article

Created At

22 Jan 2023