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Cystic Fibrosis in Egyptian Children: Achievements and Future Directions

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Last updated: 04 Jan 2025

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Abstract

Cystic fibrosis (CF) is the most common potentially lethal and life-shortening genetic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Clinical consequences of the CFTR defect are site-specific and range from severe (lungs, pancreas, male reproductive tract) to mild (intestine) to asymptomatic (sweat glands). In many developing countries CF has remained largely unrecognized, and inadequately managed, resulting in avoidable death or suffering in infancy, childhood, and adulthood. Delivering adequate CF services is met by substantial difficulties as the spectrum and distribution of CF in Egypt are still not well known. Against this background, the aim of this work is to emphasize the challenges facing initiation of a CF center in low privileged settings with the objectives of improving diagnosis, survival, and to eventually provide optimum management. Strategies for the implementation and development of CF services, as well as proper collection and documentation of patient data are therefore of vital importance. The characterization of the prevalence and molecular genetics of CF in Egypt is of utmost importance so that appropriate genetic counseling to CF patients and their families can be achieved and to pave the way for new treatment modalities.

DOI

10.21608/cupsj.2020.52045.1009

Keywords

Cystic fibrosis, Cystic fibrosis center, challenges, Future directions, Egypt

Authors

First Name

Mona

Last Name

El Falaki

MiddleName

M.

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

monafalaki@hotmail.com

City

-

Orcid

-

First Name

Mona

Last Name

El Attar

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

monamohsenm@gmail.com

City

-

Orcid

-

First Name

Nossa

Last Name

El Basha

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

noussaelbasha3@yahoo.com

City

-

Orcid

-

First Name

Nihal

Last Name

El Refai

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

nihal-r@hotmail.com

City

-

Orcid

-

First Name

Walaa

Last Name

Shahin

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

walaashahin@kasraiainy.edu.eg

City

-

Orcid

-

First Name

Hanan

Last Name

Mohsen

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

nana_mohsen2006@yahoo.com

City

-

Orcid

-

First Name

Sara

Last Name

Ali

MiddleName

-

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

dr.osarahali@gmail.com

City

-

Orcid

-

First Name

Amr

Last Name

Mustafa

MiddleName

M.

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

amrmustafa366@gmail.com

City

Cairo

Orcid

-

First Name

Dina

Last Name

Hamed

MiddleName

H.

Affiliation

Pediatric Allergy and Pulmonology Unit - Cystic Fibrosis Center. Pediatric Department, Faculty of Medicine, Cairo University, Egypt

Email

dina.alkhtaib@kasralainy.edu.eg

City

Cairo

Orcid

0000-0002-6927-5294

Volume

1

Article Issue

1

Related Issue

19715

Issue Date

2021-01-01

Receive Date

2020-12-07

Publish Date

2021-01-01

Page Start

1

Page End

6

Print ISSN

2805-279X

Online ISSN

2682-3985

Article File

CUPSJ_Volume 1_Issue 1_Pages 1-6.pdf

PDF . 628.9kB

Link

https://cupsj.journals.ekb.eg/article_132205.html

Detail API

https://cupsj.journals.ekb.eg/service?article_code=132205

Order

1

Type

Communication

Type Code

1,631

Publication Type

Journal

Publication Title

Pediatric Sciences Journal

Publication Link

https://cupsj.journals.ekb.eg/

MainTitle

Cystic Fibrosis in Egyptian Children: Achievements and Future Directions

Details

Type

Article

Created At

22 Jan 2023