Egypt has one of the most populous regions in the world. It's the Nile delta. This region has a lot of urban areas that ranges between metropolitan areas and small villages. In 1998, Tarek Abullatta concluded the possibility of the emergence of a megalopolis in Nile delta. This area extends between the two metropolitan areas of Greater Cairo and Alexandria. Meanwhile, new urban development plans and infrastructure projects were adopted and many of it had been executed. A great focus was given to developing the new cities especially those located near to the metropolises. In addition many projects of developing regional roads and increasing its capacities were progressed. Accompanied with continuing population growth at high rates, all this have resulted in urban sprawl that creating intertwined network of socio-economic relations between many adjacent human settlements in the region. This paper examines the existence of megapolitan area in Nile Delta region. It utilizes statistical tools to investigate the composition, boundaries and main characteristics of this agglomeration. It depends on data of 2006 national census. Finally, new boundaries that differ than what was previously proposed were settled.