Purpose: This paper aims to examine the impact of mission implementation dimensions (mission fulfillment and mission motivation) on organizational ambidexterity in the Pharmaceutical industry in Egypt. Methodology: The targeted population of interest is licensed Egyptian pharmaceutical companies. All the 53 companies are approached. a number of 159 questionnaires have been collected from top managers in the Egyptian pharmaceutical companies. Data are analyzed using Smart PLS v.3.3.3 to apply the Partial Least Square Structural Equation Modeling (PLS-SEM). Finding: The results showed that mission fulfillment has a significant positive effect on the Ambidexterity and on the Exploration and on the Exploitation. However it has a higher impact on exploitation then exploration. Moreover, mission motivation has a significant positive impact Ambidexterity and on exploration and on exploitation Originality: This research is aiming to fill the gap on literature in three ways. First, studying ambidexterity as a ability to balance between explorative and exploitative innovations as complementary not competing variables vital for organizational success. Second, this research fill a gap in literature by examining organizational ambidexterity from strategic perspective by examining the impact of mission fulfillment and mission motivation on organizational  ambidexterity. Since the majority of earlier studies are centered around organizational enablers and little is known about the role of strategy on ambidexterity. Third, the importance of this research become more significant in the Egyptian context especially in the Pharmaceutical sector  as Egyptian organizations in this sector are facing many challenges to pursue strategic renewal by  growing their capabilities through exploitive innovation, while offering new products and new substitutes through explorative innovation.